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KMID : 0606920110190030336
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Biomolecules & Therapeutics
2011 Volume.19 No. 3 p.336 ~ p.341
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Antioxidative Constituents of the Aerial Parts of Galium spurium
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Yang Seok-Won
Park Sae-Rom
Ahn Dal-Rae
Yang Jae-Heon
Kim Dae-Keun
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Abstract
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As part of an ongoing search for natural plants with antioxidant compounds by measuring the radical scavenging effect on 1,1-diphenyl- 2-picrylhydrazyl (DPPH), a total extract of the twigs of Galium spurium L. (Rubiaceae) was found to show potent antioxidant activity. Subsequent activity-guided fractionation of the methanolic extract led to the isolation of nine compounds, asperulosidic acid methyl ester (1), asperuloside (2), caffeic acid (3), kaempferol-3-O-L-rhamnopyranoside (4), quercetin-3-O-[α-Lrhamnopyranosyl( 1→6)-β-D-glucopyranoside] (5), isorhamnetin-3-O-glucopyranoside (6), quercetin-3-O-α-L-rhamnopyranoside (7), kaempferol-3-O-[α-L-rhamnopyranosyl(1→6)-β-D-glucopyranoside] (8), and quercetin (9). Their structures were elucidated by spectroscopic studies. Compounds 1, 3-8 were isolated for the fi rst time from this plant. Among them, compounds 3 and 9 showed the signifi cant radical scavenging effects on DPPH, and compounds 3 and 7 showed the potent ribofl avin originated superoxide quenching activities.
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KEYWORD
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Galium spurium L., Rubiaceae, Antioxidant activity, DPPH radical, Superoxide quenching activity
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